Publications
Single residue substitution in protamine 1 disrupts sperm genome packaging and embryonic development in mice
Lindsay Moritz, Samantha Schon, Mashiat Rabbani, Yi Sheng, Devon Pendlebury, Ritvija Agrawal, Caleb Sultan, Kelsey Jorgensen, Xianing Zheng, Adam Diehl, Kaushik Ragunathan, Yueh-Chiang Hu, Jayakrishnan Nandakumar, Jun Li, Kyle Orwig, Sy Redding, Sue Hammoud Nature Structure and Molecular Biology. July 17, 2023.
MBD5 and MBD6 couple DNA methylation to gene silencing through the J-domain protein SILENZIO
Lucia Ichino, Brandon A Boone, Luke Strauskulage, C Jake Harris, Gundeep Kaur, Matthew A Gladstone, Maverick Tan, Suhua Feng, Yasaman Jami-Alahmadi, Sascha H Duttke, James A Wohlschlegel, Xiaodong Cheng, Sy Redding, Steven E Jacobsen. Science. Jun 3, 2021.
Dynamic asymmetry and why chromatin defies simple physical definitions
Sy Redding Current Opinion in Cell Biology. Jun, 2021.
HP1 proteins compact DNA into mechanically and positionally stable phase separated domains
Madeline M Keenen, David Brown, Lucy D Brennan, Roman Renger, Harrison Khoo, Christopher R Carlson, Bo Huang, Stephan W Grill, Geeta J Narlikar, Sy Redding. Elife. Mar 4, 2021.
Robust Sequence Determinants of α-Synuclein Toxicity in Yeast Implicate Membrane Binding
Robert W Newberry, Taylor Arhar, Jean Costello, George C Hartoularos, Alison M Maxwell, Zun Zar Chi Naing, Maureen Pittman, Nishith R Reddy, Daniel M C Schwarz, Douglas R Wassarman, Taia S Wu, Daniel Barrero, Christa Caggiano, Adam Catching, Taylor B Cavazos, Laurel S Estes, Bryan Faust, Elissa A Fink, Miriam A Goldman, Yessica K Gomez, M Grace Gordon, Laura M Gunsalus, Nick Hoppe, Maru Jaime-Garza, Matthew C Johnson, Matthew G Jones, Andrew F Kung, Kyle E Lopez, Jared Lumpe, Calla Martyn, Elizabeth E McCarthy, Lakshmi E Miller-Vedam, Erik J Navarro, Aji Palar, Jenna Pellegrino, Wren Saylor, Christina A Stephens, Jack Strickland, Hayarpi Torosyan, Stephanie A Wankowicz, Daniel R Wong, Garrett Wong, Sy Redding, Eric D Chow, William F DeGrado, Martin Kampmann. ACS Chemical Biology. Aug 12, 2020.
Organization of Chromatin by Intrinsic and Regulated Phase Separation
Bryan A Gibson, Lynda K Doolittle, Maximillian W G Schneider, Liv E Jensen, Nathan Gamarra, Lisa Henry, Daniel W Gerlich, Sy Redding, Michael K Rosen. Cell. Oct 3, 2019.
Extending chemical perturbations of the ubiquitin fitness landscape in a classroom setting reveals new constraints on sequence tolerance
Mavor D, Barlow KA, Asarnow D, Birman Y, Britain D, Chen W, Green EM, Kenner LR, Mensa B, Morinishi LS, Nelson CA, Poss EM, Suresh P, Tian R, Arhar T, Ary BE, Bauer DP, Bergman ID, Brunetti RM, Chio CM, Dai SA, Dickinson MS, Elledge SK, Helsell CV M, Hendel NL, Kang E, Kern N, Khoroshkin MS, Kirkemo LL, Lewis GR, Lou K, Marin WM, Maxwell AM, McTigue PF, Myers-Turnbull D, Nagy TL, Natale AM, Oltion K, Pourmal S, Reder GK, Rettko NJ, Rohweder PJ, Schwarz DMC, Tan SK, Thomas PV, Tibble RW, Town JP, Tsai MK, Ugur FS, Wassarman DR, Wolff AM, Wu TS, Bogdanoff D, Li J, Thorn KS, O’Conchúir S, Swaney DL, Chow ED, Madhani HD, Redding S, Bolon DN, Kortemme T, DeRisi JL, Kampmann M, Fraser JS. Biology Open. 2018-07-23.
Sequential eviction of crowded nucleoprotein complexes by the exonuclease RecBCD molecular motor
Tsuyoshi Terakawa, Sy Redding, Timothy D Silverstein, Eric C Greene. Proc. Natl. Acad. Sci. U.S.A.. Aug 1, 2017.
Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin
Adam G Larson, Daniel Elatan, Madeline M Keenen, Michael J Trnka, Jonathan B Johnston, Alma L Burlingame, David A Agard, Sy Redding, Geeta J Narlikar. Nature. Jul 13, 2017.
Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System
Sy Redding, Samuel H Sternberg, Myles Marshall, Bryan Gibb, Prashant Bhat, Chantal K Guegler, Blake Wiedenheft, Jennifer A Doudna, Eric C Greene. Cell. Nov 5, 2015.
Base triplet stepping by the Rad51/RecA family of recombinases
Ja Yil Lee, Tsuyoshi Terakawa, Zhi Qi, Justin B Steinfeld, Sy Redding, YoungHo Kwon, William A Gaines, Weixing Zhao, Patrick Sung, Eric C Greene. Science. Aug 28, 2015.
DNA sequence alignment by microhomology sampling during homologous recombination
Zhi Qi, Sy Redding, Ja Yil Lee, Bryan Gibb, YoungHo Kwon, Hengyao Niu, William A Gaines, Patrick Sung, Eric C Greene. Cell. Feb 26,2015.
DNA dynamics and single-molecule biology
Daniel Duzdevich, Sy Redding, Eric C Greene. Chemical Reviews. Mar 26, 2014.
DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
Samuel H Sternberg, Sy Redding, Martin Jinek, Eric C Greene, Jennifer A Doudna. Nature. Mar 6, 2014.
How do proteins locate specific targets in DNA?
Sy Redding and Eric C Greene. Chem. Phys. Lett.. May 10, 2013.
The promoter-search mechanism of Escherichia coli RNA polymerase is dominated by three-dimensional diffusion
Feng Wang, Sy Redding, Ilya J Finkelstein, Jason Gorman, David R Reichman, Eric C Greene. Nat. Struct. Mol. Biol.. Feb. 20, 2013.
Single-molecule imaging reveals target-search mechanisms during DNA mismatch repair
Jason Gorman, Feng Wang, Sy Redding, Aaron J Plys, Teresa Fazio, Shalom Wind, Eric E Alani, Eric C Greene. Proc. Natl. Acad. Sci. U.S.A.. Oct. 24, 2012.